EFFECTS + BENEFITS

What is ARA 290 and how does it work?

ARA 290 is an 11-amino acid peptide designed and based on a portion of the hormone erythropoietin, which stimulates red blood cell production. However, ARA 290 does not stimulate red blood cell production, but rather it stimulates tissue repair and protection [R].

Clinical trials found that ARA 290 improves metabolic control and neuropathic symptoms in type 2 diabetics and sarcoidosis patients [R].

Benefits and uses of ARA 290

• Promotes healthy blood sugar control
• Protects neurons from oxidative stress
• Protects heart tissues
• Promotes a balanced inflammatory response
• Normalizes excess nociceptor (pain neuron) signaling in neuropathic pain

Side effects

No side effects of ARA 290 have been reported in clinical trials.

Stacks well with:

Other anti-inflammatory and neuroregenerative peptides

Ways to take:

Subcutaneous injection

What is BPC-157 and how does it work?

BPC-157 is a peptide with numerous uses. It is a 15-amino acid peptide derived from body protection compound (BPC) found in human stomach digestive juices. Studies show it accelerates healing of many tissues, including those that typically heal slowly, such as tendons and ligaments.

BPC-157 seems to also balance systemic inflammation, increase blood flow to damaged tissues, and relieve pain.

Benefits and uses of BPC-157

• Accelerates wound, skin, and tissue healing, including deep burns, ligaments, bones, and tendons
• Protects and heals gut lining
• Promotes many types of cellular repair
• Protects cells and improves cell survival with oxidative stress
• Improves blood flow to injured areas
• Relieves pain from injuries
• Protects neurons and supports healing of brain injuries
• Regulates brain serotonin and dopamine functions, possibly helping with mood
• Improves blood vessel formation
• May help with stress urinary incontinence
• Supports a healthy gut-brain axis
• Supports muscle building in response to resistance training

Side effects

• Temporary pain/redness/bruises/burning sensation at injection site
• Temporary fatigue and lethargy right after injection, so some people may use it at bedtime
• Rare and temporary side effects include nausea, dizziness, appetite changes, hot or cold flashes, and headache

Stacks well with:

• Thymosin Alpha 1
• Thymosin beta-4 or TB-500
• GHRH and GHRP peptides

Ways to take:

Oral, subcutaneous, Intra-articular

BPC-157 is a systemic peptide, so any route and location of administration will benefit the entire body. However, it may be best to administer near the location that needs the healing. So, taking it orally is better for gut healing purposes.

Part of MORPH Peptide Stacks:

• Remedy
• Flow
• Revive
• Apex
• Equilibrium
• Glow
• Fat loss
• Performance

What is CJC-1295 and how does it work?

Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.

Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.

CJC-1295 is the synthetic analog of the first 29 amino acids of growth-hormone releasing hormone (GHRH) or growth hormone secretagogue. In a clinical study, CJC-1295 increased growth hormones (GH) by 2- to 10-fold and insulin growth factor-1 (IGF-1) by 0.5- to 3-fold over the course of 9 to 11 days.

Benefits and uses of BPC-157

• Promotes muscle growth and fat loss
• Slows down aging
• Improves sleep
• Stays in the system for more than a week
• Temporarily increases GHRH

Stacks well with:

• Other growth hormone secretagogue peptides, with synergistic actions.

Ways to take:

Subcutaneous

Part of Koniver Protocols

• Neuroregen
• Flow
• Fat Loss
• Strength
• Performance

What is cerebrolysin and how does it work?

Cerebrolysin comes from an enzymatic fractionation of young pig brains. It consists of many neuroactive vitamins, short peptides, amino acids, and building blocks that support neuronal growth and function both in and outside the brain.

These active peptides include short snippets from brain-derived neurotrophic factor, nerve growth factor, ciliary nerve growth factor, P-21, enkephalins, glutathione, galanin, collagen, and orexins. Because all these components have low molecular weights, they cross the blood-brain barrier readily.

Benefits and uses

• Improves energy production, both inside and outside the mitochondria
• Protects neurons from oxidative stress, excess acidity, and excess glutamate
• Reduces amyloid deposition
• Improves synaptic function
• Improves glucose uptake into brain cells via Glut1 receptors
• Helps with cognitive function and behavioral performance
• Improves mood
• Supports recovery from concussions and brain injuries in combination with rehab programs and other treatments

Side effects

• Cerebrolysin has been around since the 1950s. It is an approved medication in 44 countries (not yet in the US). The most often reported side effects include dizziness, headache, sweating, and nausea.

Stacks well with:

• Use together or alternate with other nootropic peptides, such as Semax and selank.

Ways to take:

Short IV infusion (15 minutes)

Intramuscular injections

Subcutaneous injections

Part of MORPH Stacks

• Currently cerebrolysin is available as a stand-alone peptide.

What is DIHEXA and how does it work?

DIHEXA is a small peptide derived from the hormone angiotensin IV. It crosses the blood-brain barrier readily and has neurotrophic activities. It targets hepatocyte growth factor (HGF), which is found in high density in the cortex.

Benefits and uses

• Improves cognitive function
• Supports recovery from brain trauma
• Boosts synapse formation
• Makes nerve signals stronger
• Improves brain blood flow
• Strengthens neuronal structure
• Helps with memory acquisition and consolidation
• Supports neural differentiation and regeneration

Side effects

• Side effects of DIHEXA are rare, but may include:

• Changes in attention span
• Mood changes, which may include anxiety and irritability
• Sensory changes
• Insomnia
• Nausea

Stacks well with:

• Can be alternated with Semax, Selank, and Cerebrolysin every six weeks

What is Epithalon and how does it work?

Epithalon is the lab-made version of epithalamin, a natural pineal peptide hormone. It increases telomerase, an enzyme that helps extend the telomeres, which are the end of your chromosomes.

Telomere shortening is a marker of aging and can cause cellular senescence, when the cells can no longer divide and regenerate tissues.

Epithalon also helps with metabolism, hypothalamic sensitivity to hormones, and pituitary hormone productions. It increases lifespan in model organisms including flies, mice, and rats.

Benefits and uses

• Improves stress resistance
• Decelerates aging and cellular senescence
• Regulates and balances hormones
• Lengthens telomeres
• Reduces oxidative stress and lipid peroxidation
• Normalizes T cell function
• Protects neurons
• Normalizes melatonin loss due to aging
• Improves melatonin and cortisol circadian rhythm in older adults
• Promotes healthy DNA repair
• Improves insulin sensitivity
• Increases testosterone
• Stimulates the production of new neuron (neurogenesis)

Side effects

• The most common reported side effects of Epithalon include redness and itchiness of injection sites, and hand and leg swelling.

Stacks well with:

• Other anti-aging and anti-inflammatory peptides

Ways to take:

Subcutaneous injection

Part of MORPH Stacks

• Flow
• Apex
• Neuroregen
• Performance

What is GHK-Cu and how does it work?

GHK-Cu is a 3-amino acid peptide (glycine-histidine-lysine) with copper. It’s naturally found in the plasma, saliva, and urine. This peptide tends to decline with age.

Benefits and uses

• Supports wound healing
• Promotes balanced immune and inflammatory responses
• Antioxidant properties
• Collagen synthesis, which improves skin elasticity, density, and firmness
• Stimulates hair and nail growth
• Repairs skin sun damage and hyperpigmentation
• Activates anti-aging genes
• Skin regeneration
• Stem cell and keratinocyte growth

Side effects

• Side effects include possible copper overdose or toxicity. Also, the copper accumulation can turn the lower part of the nail blue. GHK-Cu should be used in six-week cycles, limited to four cycles per year.

Stacks well with:

• BPC-157
• Thymosin alpha 1
• Thymosin beta-4
• KPV

Ways to take:

• Topically for skin indications
• Subcutaneous injections
• Intramuscular injections

Part of MORPH Peptide Stacks

• Remedy
• Revive
• Glow

What is GHRP-2 and how does it work?

Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.

Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular health, and cognitive and mental health.

GHRPs (growth hormone releasing peptides) can boost natural growth hormone production from the anterior pituitary without the side effects of regular growth hormone supplementation. GHRP-2 is the second strongest GHRP. It binds to the growth hormone secretagogue receptor.

Aside from stimulating GH secretion, it stimulates ghrelin (hunger hormone), possibly helping with muscle gains. GHRP-2 also weakly and temporarily increases prolactin, ACTH, and cortisol.

Benefits and uses

• Promotes muscle growth
• Helps with mood and stress resilience
• Slows down aging
• Improves sleep
• Promotes a balanced inflammatory response
• Improves bone density

Side effects

• Redness, itchiness, and swelling of injection sites
• Stimulates ghrelin receptor and thus appetite (to a lesser extent than GHRP-6)
• Too high doses of GHRPs or use of GHRPs without cycling can overstimulate their receptors, reducing GH and its effectiveness
• Prolonged use and oversaturation of receptors may increase anxiety and depression
• Increases in stress responses through prolactin, and ACTH
• May cause hypoglycemia

Stacks well with:

• GHRH and other GHRPs
• BPC-157 for anabolic and tissue healing benefits

Ways to take:

Growth hormone secretagogues are best away from food, either before bed or first thing in the morning. They can be administered subcutaneously, orally, or intranasally.

MORPH Peptide Stacks

• Adonis

What is GHRP-6 and how does it work?

Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.

Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.

GHRP-6 is the third most potent GHRP. It doesn’t cause desensitization and also has less prolactin and cortisol issues than GHRP-2. It also binds to ghrelin receptors and stimulates appetite.

Benefits and uses

• Increases ghrelin in the stomach, stimulating hunger and appetite
• Increases lean mass
• Restores GH levels in obesity
• Improves stage 2 sleep
• Improves joint health

Side effects

• Strongly increases appetite
• Temporarily increases cortisol
• Redness and itchiness at injection site
• Swelling in the hands and legs
• Prolonged use and oversaturation of receptors may increase anxiety and depression
• Hot flashes

Stacks well with:

• Other GHRH and GHRPs
• BPC-157 for anabolic and tissue healing benefits

Ways to take:

Growth hormone secretagogues are best away from food, either before bed or first thing in the morning. They can be administered subcutaneously, orally, or intranasally.

Part of MORPH Peptide Stacks

• Strength

What is hexarelin and how does it work?

Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.

Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.

Hexarelin is a synthetic growth hormone-releasing peptide that stimulates GHRH release. It’s the strongest one that also increases cortisol and prolactin. However, it does not increase appetite, making it a helpful peptide for fat loss.

Benefits and uses

• Antagonizes somatostatin, allowing for muscle growth
• Potently stimulates the release of GHRH with longer lasting effect than GHRP-2 and GHRP-6
• Boosts mood
• Boosts stress resilience
• May protect neurons
• Improves bone growth
• Increases anabolism and tissue regeneration

Side effects

• Increases corticotropin-releasing hormone, cortisol, and prolactin
• Higher risk of desensitization
• Reduces delta brain wave and slow-wave (deep) sleep
• Injection site redness and itchiness
• Fluid retention in hands and legs

Stacks well with:

• GHRPs

Ways to take:

• Orally and subcutaneous injections

Part of MORPH Stacks

• Apex
• Performance
• Goddess

What is humanin and how does it work?

Humanin is a 24-amino acid peptide that naturally occurs in the mitochondria, found in many tissues and the bloodstream. It controls healthspan and lifespan in many animals. Natural humanin levels are higher in centenarians and their children compared to age-matched controls. Patients with Alzheimer’s, and mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAs) also had lower humanin levels.

In animals, humanin administration delays age-related cognitive and metabolic decline. At the same time, it protects against age-related diseases, such as stroke and cardiovascular conditions

Benefits and uses

• Boosts mitochondria functions
• Improves lifespan and healthspan
• Improves metabolic parameters, reducing the risk of cardiovascular and metabolic diseases
• Reduces inflammatory markers
• Protects neurons
• Protects healthy cells from apoptosis (cellular suicide), while promoting apoptosis in cancer cells

Side effects

• In experimental triple negative breast cancer in mice, humanin promoted tumor progression, so it may be contraindicated in cancer patients.

Stacks well with:

• MOTS-c, NAD+

What is ipamorelin and how does it work?

Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.

Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.

Ipamorelin is a 5-amino acid peptide that stimulates the pituitary to secrete GH, boost IGF-1, and inhibit somatostatin. Therefore, it supports growth and repair of muscles.

It is the mildest and most popular GHRP because it can increase GH without desensitization or any increase in cortisol and prolactin even at large doses. It also doesn’t increase hunger. Therefore, it’s the most popular GH secretagogue.

Benefits and uses

• Increases growth hormone and IGF-1
• Suppresses somatostatin without increasing hunger
• Increases bone growth
• Supports muscle growth and repair
• Supports gut recovery after bowel resection
• Supports fat loss and body composition in combination with the right training and nutrition

Side effects

• Side effects can include redness and itchiness of the injection sites and hand and feet swelling.

Stacks well with:

• Other GHRH and GH secretagogues

Ways to take:

subcutaneous

Part of MORPH Stacks

• Flow
• Fat loss
• Performance

What is kisspeptin and how does it work?

Kisspeptin is a neuropeptide hormone from the hypothalamus that stimulates the release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons through a receptor called GPR54. It helps normalize steroid hormone feedback and responses to nutrients.

Naturally-occurring kisspeptin helps stimulate sexual arousal and romance in men. It may also boost fertility outcomes and psychosexual mental health issues related to conception efforts. Kisspeptin is being researched as a potential alternative to hCG in fertility treatments.

In animal models of polycystic ovarian syndrome, kisspeptin and GnRH levels are abnormal.

Benefits and uses

• Helps with infertility and hormones
• Stimulates the hypothalamic-pituitary-gonadal axis via the GPR54 receptors
• Stimulates hypothalamic GnRH release to increase LH and FSH, in turn boosting estrogen, progesterone, and testosterone
• Increases both basal- and hCG-stimulated progesterone secretion from luteal phase uterine cells
• Increases liver antioxidants
• Boosts insulin secretion
• Temporarily increases oxytocin

Side effects

• No side effects have been reported in clinical studies.

Stacks well with:

• Other sexual health peptides, such as PT-141

Ways to take:

Subcutaneous

Part of MORPH Stacks:

• Vitality

What is it and how does it work?

KPV is a 3-amino acid peptide, lysine-proline-valine, which is a segment of melanocyte-stimulating hormone (MSH). MSH has circadian rhythm functions and anti-inflammatory properties.

KPV can enter the cells and nucleus, where your DNA is. There, it can inhibit NF-kB, your cell’s main controller of inflammatory pathways.

Benefits and uses

• Inhibits NF-kB and inflammatory MAPK signaling
• Reduces inflammatory cytokines
• Promotes a balanced inflammatory response, especially in the gut
• Promotes wound healing
• May have antimicrobial activities
• Improves skin health and regeneration

Side effects

• No side effects of KPV have been reported.

Stacks well with:

• Other Healing And Anti-Inflammatory Peptides, Such As BPC-157 And GHK-Cu

Ways to take:

• Subcutaneous
• Oral
• Transdermal

Part of MORPH Stacks

• Revive

What is LL-37 and how does it work?

LL-37 is the 37-amino acid cleavage product of human cathelicidin, an antiviral, antimicrobial, and anti-biofilm peptide. Humans produce the precursor form of this peptide in our neutrophils, natural killer cells, and in the lung lining cells.

Because LL-37 is positively charged, it can cling to and poke holes in negatively-charged bacterial cells and viral membranes. It can block the bacterial toxin called lipopolysaccharides from causing inflammation through Toll-like receptors. With its interaction with cell membranes, it can help modulate immune function.

Benefits and uses

• Help Fights Some Infections, Especially Respiratory
• Blocks Lipopolysaccharides From Interacting With TLR4 Receptors, So It Can Mitigate Metabolic Endotoxemia, And Inflammation From High-Fat Meals And Gram-Negative Bacteria
• Reduces Th2 Cytokines
• Protects Against Gut Inflammation From Gut Infections
• Helps Call Other Immune Cells To The Site
• Promotes A Balanced Immune Response
• Inhibits Macrophages’ Fever-Producing Activities

Side effects

• Although no side effects of LL-37 have been reported in the literature, and LL-37 isn’t known to cause any disease, high LL-37 is found in patients with autoimmune diseases and atherosclerosis. Those with these conditions or who are at high risk should consult their physician before using LL-37.

Stacks well with:

• Other immune peptides such as TB-500 and thymosin alpha 1.

Ways to take:

Subcutaneous, intranasal

Part of MORPH Stacks:

• Armor

What is MGF and how does it work?

MGF stands for mechano growth receptor. It’s made from parts of the IGF-1 gene, typically by mechanically overloaded muscles. The main benefit of MGF is to stimulate muscle growth, especially in tissue repair and adaptation after resistance training.

MGF as external peptides have polyethylene glycol chemically attached to them to increase their half-life and overall benefits.

Benefits and uses

• Stimulates muscle growth by activating muscle stem cells (satellite cells)
• Helps with muscle repair after exercise and during muscle stress and injury
• Supports healthy bones, joints, and their regeneration
• Protects neurons and counteracts age-related neuronal degeneration
• Supports healthy neuronal regeneration

Side effects

• Side effects of MGF are rare and may happen at excessive doses. Potential side effects include low blood sugar and swelling of extremities.

Stacks well with:

• Other anabolic peptides and growth hormone secretagogues, Semax, BPC-157

Ways to take:

• Subcutaneous
• Injection into joints (for joint indications)

Part of MORPH Stacks:

• Apex
• Strength

What is MOTS-c and how does it work?

MOTS-c is a 16-amino acid mitochondrial peptide produced mainly in muscles. It’s also detectable in other tissues and in the blood

Exercise generally boosts MOTS-c levels, so MOTS-c administration replicates many of the benefits of exercise.

Benefits and uses

• Protects the cells
• Maintains mitochondrial function and cellular viability under stressful conditions
• Regulates metabolic homeostasis
• May mitigate diet-induced insulin resistance and obesity
• Inhibits purine biosynthesis
• Activates 5’adenosine monophosphate-activated protein kinase (AMPK), increasing fat oxidation
• Increases transport of fatty acids into the mitochondria to burn for energy
• Increases fat burning and reduces production of new fat molecules
• Improves glucose uptake by bringing glucose transporter 4 (Glut4) in muscles
• Activates peroxisome proliferator-activated receptor-gamma coactivator (PGC-1alpha), which increases the generation of new and healthy mitochondria.
• PGC-1alpha then activates nuclear respiratory factors (Nrf1 and Nrf2), which turns on many antioxidant genes.
• Increases calorie burn as heat production by increasing brown fat and mitochondrial uncoupling using uncoupling protein 1 (UCP-1)
• Preserves mitochondrial function and bone mass in a mouse menopause model, with biochemical effects similar to exercise
• Improves athletic performance
• Supports weight loss effort in combination with diet and exercise
• May improve strength and muscle gain by modulating myostatin
• Protects against memory impairment from amyloid beta and lipopolysaccharides (inflammatory bacterial toxins from leaky gut) in a mouse model with intranasal delivery
• May boost longevity

Side effects

• No side effects have been reported in clinical trials.

Stacks well with:

• Can be cycled with other mitochondrial peptides

Ways to take:

Subcutaneous and intranasal

Part of MORPH Stacks:

• Super Mito Fitness
• Fat Burner +

What is PE-22-28 and how does it work?

PE-22-28 is a 7-amino acid derivative of Spadin, which blocks the TREK-1 channel in the brain. Chronic, unpredictable mild stress increases TREK-1 in the hippocampus, a region that controls mood, memory, and learning. The TREK-1 increase may allow for stress-induced cognitive impairment and low mood, so blocking it seems to preserve cognitive performance and mood during stress. Mice studies showed that PE-22-28 reduced immobility time and delay to eating food. It also boosts neuronal growth and connections, and protects neurons from excitotoxicity.

Benefits and uses

• Improves mood and motivation
• Induces neurogenesis and synaptogenesis
• Improves firing rates of serotonin neurons
• Protects neurons from excess glutamate
• Improves the brain’s stress resilience
• Preserves cognitive performance amidst stress

Side effects

• PE-22-28 is well-tolerated, and so far no side effects have been reported.

Stacks well with:

• Other neuroregenerative peptides

Ways to take:

• Oral and subcutaneous

Part of MORPH Stacks:

• Neuroregen

What is pinealon and how does it work?

Pinealon is a 3-amino acid peptide that can reverse brain aging and protect brain tissues against hypoxia and cellular suicide (apoptosis). Due to its small size, it can cross the blood-brain barrier. Once it enters the cells, it can directly interact with DNA and change genetic readouts.

Benefits and uses

• Helps with memory and attention
• Protects neurons against damages and oxidative stress, including from lack of oxygen or blood flow
• Promotes neurogenesis
• Geroprotective and anabolic
• Increases cellular resistance to oxidative damage and counteracts oxidative stress
• May protect the brain from high homocysteine, a neurotoxic amino acid
• Protects muscle cells from damage during exercise
• Stimulates weight loss
• May increase serotonin levels
• Promotes healthy circadian rhythm and improves sleep
• Improves red blood cell membrane health and reduces lipid peroxidation
• Boosts mood and brain function

Side effects

• No side effects have been reported in clinical trials.

Stacks well with:

• other anti-aging and melanocortin peptides

Ways to take:

• subcutaneous and oral

Part of MORPH Stacks:

• Apex
• Vitality

What is PT-141 (bremelanotide) and how does it work?

PT-141 is a libido-boosting peptide. It’s a synthetic peptide analog of alpha-MSH, which is a neurohormone in the melanocortin system. It works by activating the MC3R and MC4R receptors in the brain. Intranasal use of this peptide causes erection in many animals and humans. However, PT-141 doesn’t cause the drop in blood pressure, unlike current erectile drugs, suggesting that it doesn’t work through the cardiovascular system.

The melanocortin system controls metabolism and appetite, along with heart health, stress response, and sexual function. Alpha-melanocyte stimulating hormone (alpha-MSH) can modulate the nervous and immune systems. It also has anti-inflammatory and anti-microbial activities.

In the skin, alpha-MSH also influences skin darkness. However, unlike melanotan 2, PT-141 does not cause skin darkening.

Benefits and uses

• Increases sexual desire, motivation, and arousal across genders
• Induces erectile response
• Improves genital sensation and pleasure
• May help with discomfort and orgasm during intercourse
• May help with emotional issues around sex
• Improves heart health and metabolism
• Promotes healthy blood pressure
• Promotes healthy stress response

Side effects

• Side effects can include flushing and nausea and redness and irritation around the injection site.

Stacks well with:

• other sexual health peptides such as kisspeptin.

Ways to take:

Intranasal and subcutaneous

Part of MORPH Stacks:

• Goddess
• Vitality

What is thymalin and how does it work?

Thymalin is a mix of peptides from the thymus that can help regulate immune function and support the body’s natural ability to fight infections. It is also geroprotective, anti-aging, and may protect against all-cause mortality.

In mice, thymalin reduces all-cause mortality and prolongs lifespan.

Benefits and uses

• Supports a balanced immune response
• Promotes immune system readiness
• Regulates circadian rhythm and sleep-wake cycle
• May reduce all-cause mortality
• Supports healthy recovery from respiratory illnesses

Side effects

• No side effects have been identified in clinical studies.

Stacks well with:

• Other pineal, immune, and tissue healing peptides

Ways to take:

• Subcutaneous

Part of MORPH Stacks:

• Flow
• Apex

What is thymosin alpha 1 and how does it work?

Thymosin alpha 1 is a 28-amino acid peptide naturally found in the human thymus. While it helps modify, enhance, and restore immune function at the right time, it also promotes a balanced immune response and prevents excessive activation. Most importantly, it works with your body’s natural immune responses.

In 35 countries, a synthetic form of thymosin alpha 1 is an approved medication for hepatitis B and C and supports immune function in other situations. However, in the US, it remains an experimental treatment.

Benefits and uses

• Anti-aging for T cells and thymus
• Promotes T cell differentiation
• Protects T cell from apoptosis (cellular death)
• Improves Th1 (antibacterial and antiviral) responses
• Promotes a balanced immune response
• Improves antigen presentation and antibody responses
• Protects against oxidative damage
• Helps with stress, mood, and HPA axis dysfunction
• Improves metabolism and weight management
• May help normalize inflammatory responses, such as food reactions
• Supports natural antimicrobial responses
• Promotes wound and tissue healing processes

Side effects

• Local irritation, redness, itchiness, and discomfort at injection site.

Stacks well with:

• BPC-157, thymosin beta 1, GHK-Cu

Ways to take:

• Subcutaneous

Part of MORPH Stacks:

• Apex
• Armor
• Remedy

What is thymosin beta-4 and how does it work?

Thymosin beta-4 is a 43-amino acid derivative of thymosin, a hormone from the thymus that stimulates T cell production. However, TB-500 is naturally found in most cells. Naturally, the gene that produces this peptide tends to be the first to become dysregulated after injuries.

It can control how actin forms strands that provide structures to the cells. In animal studies, it promoted the formation of new blood vessels, wound repair, and hair growth.

Benefits and uses

• Promotes wound and tissue healing
• Increases blood vessel formation
• Promotes hair growth, especially in conjunction with PRP
• Promotes Th1/Th2 balance

Side effects

• Side effects include temporary fatigue and lethargy. Although there is no evidence that this peptide causes cancer, there are concerns that it can contribute to carcinogenesis.

Stacks well with:

• Other immune and healing peptides, such as thymosin alpha 1 and BPC-157

Ways to take:

• Subcutaneous

Part of MORPH Stacks:

• Apex
• Equilibrium
• Glow

What is tesamorelin and how does it work?

Growth hormone is a very important anti-aging hormone that helps with cell growth and metabolic efficiency. It also helps with the production of IGF-1 to reproduce and regenerate cells. But your body has a negative feedback system for growth hormone, so injecting GH leads to too much IGF-1, which accelerates cellular aging.

Whereas, growth hormone-releasing hormone (GHRH) gently stimulates the pituitary to release growth hormones without activating the negative feedback. So, you can get the anti-aging, muscle-building, and fat-loss benefits of growth hormone without the side effects of growth hormone injections.

Tesamorelin is a GHRH that increases IGF-1 without disrupting its negative feedback loop. It was initially approved to treat HIV-associated lipodystrophy (increase in mid-section fat between organs due to antiretroviral drugs).

Benefits and uses

• Helps with bone density
• Supports muscle and lipid metabolism
• Promotes a balanced inflammatory response
• Supports heart health
• Helps with fat loss, especially belly fat and dangerous fat between organs
• Boosts cognitive function
• Improves cognitive function in seniors with age-related cognitive decline and mild cognitive impairment, including those with ApoE4 gene

Side effects

• Increases IGF-1 (when not desired)
• May cause glucose intolerance and increase the risk of diabetes
• Injection site redness, irritation, and itchiness
• Muscle aches
• Hand and leg swelling
• Contraindicated in pregnancy and those with pituitary conditions

Stacks well with:

• Ipamorelin
• CJC-1295
• Hexarelin

Ways to take:

• Subcutaneous injection

Part of MORPH Stacks:

• Fat Loss
• Goddess

What is Selank (TP-7) and how does it work?

Selank is a 7-amino acid peptide created by joining Tuftsin with another three amino acids to make it more stable. As a synthetic analog of Tuftsin, a 4-amino acid that is part of immunoglobulin G, it has some immune-stimulating effects.

Benefits and uses

• Anti-ulcer and promotes a strong gut mucosal barrier
• Promotes healthy relaxation response by increasing the effects of GABA
• Increases BDNF in the hippocampus, possibly boosting mood and cognitive function
• Improves sleep vs. wakefulness balance
• Helps regulate inflammation, especially through IL-6 and helper T cells
• Regulates monoamine neurotransmitters
• Regulates BCL-6, which controls T cell-mediated immune responses
• Supports antiviral immune function
• Helps with insulin resistance and metabolism

Side effects

• Excess doses can lead to desensitization.

Stacks well with:

• Can be alternate with Semax.
• Other immune peptides such as TB-500 and thymosin alpha 1.

Ways to take:

• Subcutaneous and intranasal

Part of MORPH Stacks:

• Armor
• Goddess
• Apex

What is Semax and how does it work?

Semax is a 7-amino acid peptide that comes from amino acids 4 – 10 of the adrenocorticotropic hormone (ACTH). Typically, the body produces ACTH as a stress hormone, but Semax in particular has many unique properties, such as stimulating neuronal growth and immune function. It’s said to induce the good parts of stress, such as the high and enhanced performance, without the anxiety. So, you can perform and learn with minimal resistance and procrastination.

As a melanocortin, it acts at many places throughout the body, which is why it helps with the immune system, gut health, and brain function.

N-acetyl semax is a synthetic form that is better absorbed and can better cross the blood-brain barrier.

Benefits and uses

• Increases BDNF
• Increases dopamine and serotonin signaling, boosting mood and motivation
• Improves stress resilience and promotes a balanced stress response
• Blocks melanocortin receptors (MC3R and MC4R)
• Boosts immune function efficiency
• Protects neurons and supports neuronal healing
• Supports the healing processes of the stomach lining
• May be used preventively
• Thins the blood
• Improves physical performance and adaptation to high-intensity exercise
• Improves memory, focus, attention span, and verbal fluency
• Improves blood flow to the brain
• May block pain signaling through enkephalin
• Protects delicate neurons in the eyes
• May facilitate lucid dreaming
• May potentiate other stimulants
• Boosts confidence and wellbeing
• Antioxidant properties

Side effects

• Excess and prolonged use can lead to desensitization.
• The effects tend to last a few hours. Susceptible people may feel low mood and motivation once the effects wear off, so people with pre-existing mental health conditions should consult their physician before use.
• Hair loss

Stacks well with:

• other nootropic peptides such as cerebrolysin
• May be alternated with Selank

Ways to take:

• Subcutaneous and intranasal

Part of MORPH Stacks:

• Apex
• Adonis
• Strength (N-acetyl form)